AKAP12 — A-kinase anchoring protein 12
AKAP12 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKAP12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-Niche Fibroblast Developmental | AHNAK, AHNAK2, CELF2, CYSLTR1, DPYSL3, DST, GAS6, HSPG2 +10 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, CIT, COL27A1, ITGB4, LGI4, NRP2, SAMHD1, SYT10 | View in SCUBA |
| Lymphatic endothelial | Leukotriene Biosynthesis Lipid metabolism | ADIRF, APOLD1, EMP1, ITM2A, LTC4S, PLAC9, SNCG, THBD | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1, IL1R1 +6 more | View in SCUBA |
About the gene
| Synonyms | AKAP250, SSeCKS |
|---|---|
| Chromosome | 6: 151239967-151358559 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
Function
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.