CYSLTR1 — Cysteinyl leukotriene receptor 1

CYSLTR1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CYSLTR1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	MHC-I Antigen Presentation Anti-viral	B2M, BANK1, CD48, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F +1 more	View in SCUBA
CD4⁺ T cells	Naive T cell T cell development	AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, ENC1 +21 more	View in SCUBA
Endothelial	Vasoactive GPCR Signaling Endothelial cell development	APLNR, BAIAP2L1, CALCRL, COPZ2, ETS2, FAM110D, FAM167B, IFI16 +10 more	View in SCUBA
Fibroblasts	Wnt-Niche Fibroblast Developmental	AHNAK, AHNAK2, AKAP12, CELF2, DPYSL3, DST, GAS6, HSPG2 +10 more	View in SCUBA
Hematopoietic progenitor cells	ILC/NK Development Lymphcyte development	ACY3, ADGRD1, ATP10A, CCDC141, CD3E, ID2, ITGB7, NFATC4 +7 more
Macrophages	Macrophage Identity Innate immunity	CCDC88B, CSF1R, CYP4V2, EVL, FAM53B, FOXRED2, GATM, GPR155 +15 more	View in SCUBA

About the gene

Synonyms	CysLT(1), CysLT1, CYSLT1R
Chromosome	X: 78271468-78327691
Predicted location	Membrane
Essential gene	No
Protein class	FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Molecular function	G-protein coupled receptor, Receptor, Transducer

Function

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.