PYCR1 — Pyrroline-5-carboxylate reductase 1
PYCR1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PYCR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mucin Glycosylation Biosynthesis Mucus production | AGR2, ANG, AP2B1, ASRGL1, FAM3C, FAM3D, GAPDH, GNPNAT1 +13 more | View in SCUBA |
About the gene
| Synonyms | P5C |
|---|---|
| Chromosome | 17: 81932384-81942412 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Amino-acid biosynthesis, Proline biosynthesis, Stress response |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5- carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in the cellular response to oxidative stress.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.