ASRGL1 — Asparaginase and isoaspartyl peptidase 1
ASRGL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASRGL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ATP8B1, BMP1, BMPR2, CLIP1, CMIP, EHBP1L1 +18 more | View in SCUBA |
| Hematopoietic progenitor cells | ER Protein Folding Housekeeping | CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2, MLEC +13 more | |
| Pericytes | Pericyte Identity Developmental | AIF1L, ALPL, ARL15, EDN1, FAM89A, GFOD1, LPCAT2, OCIAD2 +1 more | View in SCUBA |
About the gene
| Synonyms | ALP, ALP1, FLJ22316 |
|---|---|
| Chromosome | 11: 62337448-62393412 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease |
Function
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp- L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.