AGR2 — Anterior gradient 2, protein disulphide isomerase family member
AGR2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucin Folding Machinery Mucus production & secretion | KDELR2, MYDGF, OSTC, PPIB, SEC11C, SEC61B, SEC61G, SSR3 | View in SCUBA |
About the gene
| Synonyms | AG2, HAG-2, PDIA17, XAG-2 |
|---|---|
| Chromosome | 7: 16791811-16833433 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.