Mucin Glycosylation Biosynthesis
Gene co-expression module in Colonocytes
| Category | Mucus production |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes: ST6GALNAC1 (sialyltransferase, mucin O-glycosylation), GNPNAT1 (glucosamine-phosphate N-acetyltransferase, hexosamine pathway), FAM3D (cytokine-like, secreted), SND1 (RNA-binding/transcriptional coactivator), AGR2 (anterior gradient 2, ER chaperone for mucins, enriched in inf_colono), PGD (6-phosphogluconate dehydrogenase, pentose phosphate), GAPDH (glycolysis), SSR4 (translocon), TMED3 (COPI vesicle), TKT (transketolase, pentose phosphate), PDIA5 (protein disulfide isomerase, ER), NOX1 (NADPH oxidase 1, reactive oxygen species), MTHFD2 (one-carbon metabolism), PYCR1 (proline synthesis), GPI (glycolysis). The combination of mucin glycosylation (ST6GALNAC1, GNPNAT1), ER chaperones for mucins (AGR2, PDIA5, SSR4), secretory pathway (TMED3), and metabolic support (pentose phosphate, glycolysis, proline synthesis) points to a goblet cell/secretory colonocyte mucin biosynthesis and glycosylation program. FAM3D is a secreted intestinal factor. NOX1 is expressed in colonocytes and supports barrier function. This module represents the biosynthetic and metabolic support for mucin production.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.91
- ER Protein Processing · correlation 0.90
- ER-Golgi Trafficking · correlation 0.90
- Protein Homeostasis Housekeeping · correlation 0.89
- Proteasome Activity · correlation 0.83
- Mitochondrial Peroxisomal Metabolism · correlation 0.83
- Unfolded Protein Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.