RABGEF1 — RAB guanine nucleotide exchange factor 1
RABGEF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RABGEF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Monocytes | Inflammatory Autophagy Lysosomal & pahgocytosis | ATG2A, MAP1LC3B, RELT, SESN2, TOM1, UBALD2, UPP1 | View in SCUBA |
About the gene
| Synonyms | rabex-5, RABEX5 |
|---|---|
| Chromosome | 7: 66682164-66811464 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Endocytosis, Protein transport, Transport, Ubl conjugation pathway |
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.