ANKHD1 — Ankyrin repeat and KH domain containing 1
ANKHD1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKHD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Stress Epigenetic Silencing DNA/chromatin regulation | ALKBH5, EPC2, FAM53C, MXD1, NEU1, OTUD4, PHF1, PNO1 +8 more | |
| Macrophages | Integrated Stress Response Stress | AKAP17A, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD, GPS2 +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ARID1A, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3, ELF1 +5 more |
About the gene
| Synonyms | FLJ10042, FLJ11979, FLJ14127, FLJ20288, KIAA1085, MASK, MASK1 |
|---|---|
| Chromosome | 5: 140401814-140539856 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
Function
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.