Integrated Stress Response
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 26 genes have a known function matching the annotation |
Why this annotation
Top hub genes include IRF9 (interferon regulatory factor 9, core component of ISGF3 complex for type I/III IFN signaling), DDIT3 (CHOP/GADD153, integrated stress response/ER stress transcription factor), ID3 (inhibitor of differentiation, BMP/Notch signaling), GPS2 (transcriptional corepressor, NF-κB and nuclear receptor regulation), IFI30 (GILT, lysosomal thiol reductase for antigen processing), CSF2RA (GM-CSF receptor alpha), PSMA6 (proteasome subunit), SLC7A5 (LAT1, amino acid transporter linked to mTOR/stress). IRF9 is the clearest functional anchor pointing to interferon signaling, but DDIT3 (ER/integrated stress) and the overall weak coherence suggest this module mixes interferon response with integrated stress response elements. The module is weakly coherent with uniform expression across subsets for most genes.
Genes
AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD, GPS2, H2AC6, ID3, IFI30, IRF9, MED17, NPIPB5, NXT1, PIGA, PSMA6, RABGEF1, RASSF5, RBM4, SLC7A5, SNAI1, SPRY2, USE1, ZFAND2A
Most correlated modules
- Lipid-Sensing Transcriptional · correlation 0.86
- Autophagy Lysosomal · correlation 0.82
- Stress Response Transcription · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.