RELT — RELT TNF receptor
RELT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RELT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Effector ISG Anti-viral | GOLGA7B, KIF5C, KIT, MAP2K6, MVB12B, NMUR1, PLCG1, PLOD3 +8 more | View in SCUBA |
| Monocytes | Inflammatory Autophagy Lysosomal & pahgocytosis | ATG2A, MAP1LC3B, RABGEF1, SESN2, TOM1, UBALD2, UPP1 | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Survival Signaling Immune regulation | BIRC2, CWC25, GATA3, IL4I1, KPNA2, OAT, OTULIN, PIM2 +4 more |
About the gene
| Synonyms | FLJ14993, TNFRSF19L |
|---|---|
| Chromosome | 11: 73376399-73397474 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.