PIM2 — Pim-2 proto-oncogene, serine/threonine kinase
PIM2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Integrated Stress Response Stress | AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1 +4 more | View in SCUBA |
| CD4⁺ T cells | MAPK feedback signaling TCR/AP1/NFKb pathway | BACH1, DUSP16, DUSP4, E2F3, EPSTI1, MAT2B, PELI1, SEC14L1 +2 more | View in SCUBA |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Survival Signaling Immune regulation | BIRC2, CWC25, GATA3, IL4I1, KPNA2, OAT, OTULIN, RAB21 +4 more | |
| Natural Killer cells | NK/ILC Differentiation Differentiation | ARHGAP9, CHKA, CHPT1, PITPNC1, PPP1R16B, STAM, ZBTB16 | View in SCUBA |
About the gene
| Chromosome | X: 48913182-48919024 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis, Cell cycle |
Function
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro- apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.