NF-κB Survival Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
STX11 is a SNARE protein essential for cytotoxic lymphocyte degranulation (mutations cause hemophagocytic lymphohistiocytosis). IL4I1 is an immunomodulatory enzyme expressed in activated T cells. BIRC2 and PIM2 promote cell survival. OTULIN is a linear deubiquitinase that regulates NF-κB and cell death. GATA3 is a key T helper/MAIT cell transcription factor. RELT is a TNF receptor family member. KPNA2 mediates nuclear import of immune transcription factors. This module reflects NF-κB-linked survival and cytotoxic granule/immune effector programs in activated MAIT cells.
Genes
BIRC2, CWC25, GATA3, IL4I1, KPNA2, OAT, OTULIN, PIM2, RAB21, RELT, SDCBP, STX11, YIPF5
Most correlated modules
- Metabolic Homeostasis · correlation 0.88
- Rho GTPase Migration · correlation 0.88
- Tissue Residency · correlation 0.85
- NF-κB Activation · correlation 0.83
- Splicing Regulation · correlation 0.79
- cAMP Immune Regulation · correlation 0.77
- Tissue Residency Regulation · correlation 0.77
- NF-κB RNA Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.