RHAG — Rh associated glycoprotein
RHAG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHAG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Mature Erythrocyte Erythropoietic | AHSP, ANK1, APOC1, CA1, CD36, CD40LG, CDH1, FAM178B +4 more |
About the gene
| Synonyms | CD241, RH50A, SLC42A1 |
|---|---|
| Chromosome | 6: 49605175-49636839 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Ammonia transport, Transport |
Function
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane. The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. In vitro, leaks monovalent cations. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.