RTCB — RNA 2',3'-cyclic phosphate and 5'-OH ligase
RTCB belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RTCB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial OxPhos Mitochondrial & OxPhos | ABRACL, ACO2, CALM1, CD9, CNBP, CNIH4, ETHE1, FDX1 +13 more | View in SCUBA |
About the gene
| Synonyms | C22orf28, FAAP, HSPC117 |
|---|---|
| Chromosome | 22: 32387582-32412248 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | tRNA processing |
Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.