CNBP — CCHC-type zinc finger nucleic acid binding protein
CNBP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Translation Initiation Housekeeping | CCNI, CD99, EIF3E, EIF3F, ESD, HNRNPA1, ITM2B, LAPTM4A +3 more | View in SCUBA |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ANXA7, ARF3, ATP5MC3, CD320, CD74, COX6A1, COX6B1, IL2RG +10 more | View in SCUBA |
| Lymphatic endothelial | Cytoskeletal Housekeeping Cytoskeletal | ARPC5, C11orf58, CD81, DYNLT1, GYPC, PPP1CA, SYPL1, TMBIM6 +3 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Smooth muscle cells | Basal Metabolic Housekeeping Housekeeping | ARPC2, C11orf58, C1orf43, C4orf3, COX17, GUK1, HNRNPDL, HNRNPH2 +6 more | View in SCUBA |
About the gene
| Synonyms | CNBP1, DM2, RNF163, ZCCHC22, ZNF9 |
|---|---|
| Chromosome | 3: 129167827-129183922 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Binds to RNA. Binds to RNA. Binds to RNA. Binds to RNA. Binds to RNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.