CD9 — CD9 molecule
CD9 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Redox Detoxification Stress | CDX1, CYBA, GSTK1, GSTP1, KRT18, PYCARD, SEC61B, SERPINB5 +3 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CPED1, DMD +10 more | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, DAPK2, DENND1B +8 more | |
| Glial cells | Glial Myelination Identity Myelination | AP1S2, CALM2, CD81, COMT, GPM6B, GSN, IGFBP7, LGALS1 +6 more | View in SCUBA |
| Goblet cells | Goblet Cell Identity Mucus production & secretion | AGR3, CA12, FAM162A, IL1R2, LGALS4, NDUFA1, SCP2, TMEM141 +1 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, DRAM1 +21 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | AHI1, CD81, CPED1, EDIL3, FHL1, GSN, JUND, MAF +3 more | View in SCUBA |
About the gene
| Synonyms | BA2, MIC3, MRP-1, P24, TSPAN29 |
|---|---|
| Chromosome | 12: 6199715-6238271 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Cell adhesion, Fertilization |
Function
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation. Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.