SLC10A2 — Solute carrier family 10 member 2
SLC10A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC10A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ADAMTSL1, KHDRBS2, LIN7A, OPCML, PAQR5, PIGZ, PLCL1, RALYL +3 more | View in SCUBA |
About the gene
| Synonyms | ASBT, IBAT, ISBT, NTCP2 |
|---|---|
| Chromosome | 13: 103043998-103066417 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Lipid transport, Sodium transport, Symport, Transport |
Function
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.