PLCL1 — Phospholipase C like 1 (inactive)
PLCL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLCL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling activation TCR/AP1/NFKb pathway | CNST, CORO1B, DAPP1, ECI1, FAAH2, FCMR, GPCPD1, KLHL24 +8 more | View in SCUBA |
| Endothelial | EC Inflammatory Activation Inflammation | ARHGAP4, ARHGEF2, ARL15, ATP13A3, CAPZA2, CD58, GFOD1, GJA4 +12 more | View in SCUBA |
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ADAMTSL1, KHDRBS2, LIN7A, OPCML, PAQR5, PIGZ, RALYL, RFLNB +3 more | View in SCUBA |
About the gene
| Synonyms | PLC-L, PLCE, PLCL, PPP1R127, PRIP |
|---|---|
| Chromosome | 2: 197804593-198572581 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Transducer |
Function
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.