SLC11A1 — Solute carrier family 11 member 1
SLC11A1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC11A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
| Monocytes | FPR1 Innate Sensing Innate immunity | CD300LF, FPR1, FYN, OSCAR, SELPLG, SIRPB1, SULF2, SYTL1 +1 more | View in SCUBA |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CLEC7A, CSF2RB, CSF3R, CYTH4, FCGR2A, LY96, SLC25A37 +1 more |
About the gene
| Synonyms | LSH, NRAMP, NRAMP1 |
|---|---|
| Chromosome | 2: 218382029-218396894 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Iron transport, Transport |
Function
Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.