SLC9A3 — Solute carrier family 9 member A3
SLC9A3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC9A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical Na+/H+ transport Absorption | COL17A1, CTSA, GNG12, LHFPL2, MICAL2, PLS1, SLC6A20 | View in SCUBA |
About the gene
| Synonyms | NHE-3, NHE3 |
|---|---|
| Chromosome | 5: 470456-524449 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Antiport, Ion transport, Sodium transport, Transport |
Function
Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.