GNG12 — G protein subunit gamma 12
GNG12 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNG12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Inflammation | ANKS1A, APH1B, ARL4A, BZW2, C1orf21, CCNG1, CCNG2, DNPH1 +9 more | View in SCUBA |
| Enterocytes | Apical Na+/H+ transport Absorption | COL17A1, CTSA, LHFPL2, MICAL2, PLS1, SLC6A20, SLC9A3 | View in SCUBA |
| Fibroblasts | Rho-ROCK Contractility Cytoskeletal | ANXA6, ATP2B4, CBX6, CSDE1, DYNLT3, ITM2C, PPP1CB, ROCK1 +1 more | View in SCUBA |
About the gene
| Chromosome | 1: 67701475-67833467 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Transducer |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.