Apical Na+/H+ transport
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 8 genes have a known function matching the annotation |
Why this annotation
SLC9A3 (the NHE3 sodium/hydrogen exchanger) and SLC6A20 (an amino-acid transporter) are apical absorptive transporters. PLS1 (plastin-1) bundles microvillar actin. COL17A1 and MICAL2 suggest adhesion and cytoskeletal remodeling, and CTSA, LHFPL2 and GNG12 are peripheral members. The label chosen is apical ion and nutrient transport, consistent with the absorptive neighbors in this batch.
Genes
COL17A1, CTSA, GNG12, LHFPL2, MICAL2, PLS1, SLC6A20, SLC9A3
Most correlated modules
- Brush-border enterocyte · correlation 0.88
- Surface colonocyte lipid-droplet · correlation 0.85
- Enterocyte fatty-acid catabolism · correlation 0.85
- Colonocyte differentiation signaling · correlation 0.83
- Chylomicron lipid absorption · correlation 0.82
- Epithelial junction polarity · correlation 0.82
- ER-autophagy homeostasis · correlation 0.79
- Stress-responsive transcription · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.