SMPDL3B — Sphingomyelin phosphodiesterase acid like 3B
SMPDL3B belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMPDL3B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Lipid Metabolism Nutrient processing | AKAP7, ARSD, CCND1, DAPL1, EMC10, GALK1, GHR, KLK1 +18 more | View in SCUBA |
About the gene
| Synonyms | ASML3B |
|---|---|
| Chromosome | 1: 27935000-27959157 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Glycosidase, Hydrolase |
| Biological process | Immunity, Inflammatory response, Innate immunity, Lipid degradation, Lipid metabolism |
Function
Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.