SPDEF — SAM pointed domain containing ETS transcription factor
SPDEF belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPDEF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Goblet Secretory Identity Mucus production & secretion | ARFIP2, C12orf57, CREB3L4, FRZB, GMDS, HID1, HSPA2, KCNMA1 +8 more | View in SCUBA |
About the gene
| Synonyms | bA375E1.3, PDEF |
|---|---|
| Chromosome | 6: 34537802-34556333 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.