FRZB — Frizzled related protein
FRZB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRZB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT-modulating Fibroblast Developmental | CIB2, COL4A5, DMKN, F3, FIP1L1, GPSM3, HSD17B2, INSC +9 more | View in SCUBA |
| Goblet cells | Goblet Secretory Identity Mucus production & secretion | ARFIP2, C12orf57, CREB3L4, GMDS, HID1, HSPA2, KCNMA1, LRRC26 +8 more | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, CSRP2, DACH1, EFEMP1, GULP1, MASP1, NDUFAF4 +3 more | View in SCUBA |
| Smooth muscle cells | Wnt-Notch Modulation Development | CLMN, HES4, LBH, MAP3K7CL, NET1, NRGN, NRIP2, PHLDA2 +1 more | View in SCUBA |
About the gene
| Synonyms | FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, hFIZ, SFRP3, SRFP3 |
|---|---|
| Chromosome | 2: 182833275-182866637 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Wnt signaling pathway |
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.