HSPA2 — Heat shock protein family A (Hsp70) member 2
HSPA2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSPA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immediate early response Stress | ABHD5, CEBPB, CITED2, FAM53C, GADD45A, GADD45B, HEXIM1, IER5L +9 more | View in SCUBA |
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, ISG20L2, MAP3K13, MLF1, MORN3, PABPC4 +7 more | View in SCUBA |
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR +19 more | View in SCUBA |
| Glial cells | Hypoxia mTOR Stress Stress | AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, IFRD1, INTS6, NEU1 +3 more | View in SCUBA |
| Goblet cells | Goblet Secretory Identity Mucus production & secretion | ARFIP2, C12orf57, CREB3L4, FRZB, GMDS, HID1, KCNMA1, LRRC26 +8 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HES5 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more |
About the gene
| Chromosome | 14: 64535905-64546173 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Differentiation, Spermatogenesis, Stress response |
Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.