Goblet Secretory Identity
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
XBP1 is the master IRE1-spliced UPR transcription factor and the primary driver of secretory cell ER expansion. CREB3L4 (OASIS family) is a second UPR-responsive transcription factor active in secretory cells. SPDEF is the SAM-pointed domain ETS factor that drives goblet cell differentiation and mucin expression. LRRC26 and KCNMA1 together form the BK channel complex that regulates Ca2+-activated mucus secretion. HID1 controls dense-core vesicle trafficking from the Golgi. GMDS provides GDP-fucose for fucosylation of mucins. SELENOM is an ER selenoprotein. FRZB is a secreted Wnt antagonist. SPINK1 is a goblet/Paneth cell secreted inhibitor. This module integrates UPR transcriptional regulation with goblet cell identity (SPDEF) and secretory vesicle/ion channel machinery, representing a goblet cell secretory differentiation and UPR transcriptional program.
Genes
ARFIP2, C12orf57, CREB3L4, FRZB, GMDS, HID1, HSPA2, KCNMA1, LRRC26, RAP1GAP, SELENOM, SF3B5, SPDEF, SPINK1, WIPI1, XBP1, ZNF511
Most correlated modules
- Mucin O-Glycosylation · correlation 0.85
- Mucin Folding Machinery · correlation 0.84
- ERAD ER Homeostasis · correlation 0.83
- ER Protein Translocation · correlation 0.82
- UPR Chaperone Response · correlation 0.81
- N-Glycosylation ER Stress · correlation 0.78
- ER Targeting ERAD · correlation 0.77
- Goblet Secretory Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.