SYNJ1 — Synaptojanin 1
SYNJ1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYNJ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
About the gene
| Synonyms | INPP5G, PARK20 |
|---|---|
| Chromosome | 21: 32628759-32728040 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, RNA-binding |
| Biological process | Endocytosis, Lipid metabolism |
Function
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.