TARDBP — TAR DNA binding protein
TARDBP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TARDBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Surveillance/NMD RNA processing & translation | AFG3L2, ANKRD13A, ARPP19, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20 +8 more | |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
About the gene
| Synonyms | ALS10, TDP-43 |
|---|---|
| Chromosome | 1: 11012344-11030528 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor, RNA-binding |
| Biological process | Biological rhythms, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Function
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6. Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.