Autophagy Vesicular Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 41 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 41 genes have a known function matching the annotation |
Why this annotation
Hub genes include BECN1 (autophagy initiation), TGOLN2 (trans-Golgi network), SFT2D2 (Golgi SNARE), EHBP1L1 (endosomal), ACTR2 (Arp2/3 actin branching), SEPTIN2 (cytoskeletal), CAPRIN1 (stress granule/RNA), LARP1 (RNA-binding), PCBP2 (RNA-binding), UHMK1 (kinase). The module is weakly coherent with all genes showing weak membership, suggesting a mixed housekeeping program. BECN1, TGOLN2, SFT2D2, and EHBP1L1 point toward vesicular/membrane trafficking and autophagy. In the context of neighboring modules that also contain cytoskeletal and RNA-processing genes, this module represents general cellular housekeeping with an autophagy/vesicular trafficking component. PRKAR1A (PKA signaling) and DAZAP2 add regulatory diversity. The overall signature is most consistent with general housekeeping/autophagy-vesicular machinery.
Genes
ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1, CPSF2, CSDE1, DAZAP2, EHBP1L1, FAM120A, FBXO7, IARS2, IFNAR1, ITPRID2, JKAMP, KIAA0930, LARP1, LASP1, NDUFS1, NFE2L1, PCBP2, PPP2R1A, PRKAR1A, PTBP3, RAB5B, RAP2B, SEPTIN2, SFT2D2, SNX14, TARDBP, TGOLN2, TMEM248, TMEM30A, TMEM87B, TRAM1, UFL1, UHMK1, WDR82
Most correlated modules
- ER Membrane Homeostasis · correlation 0.98
- ER Protein Quality Control · correlation 0.97
- Nuclear Pore Transport · correlation 0.97
- Myeloid Innate Signaling · correlation 0.96
- Macrophage Endocytic Signaling · correlation 0.95
- TGF-beta Signaling · correlation 0.95
- ER-Lysosome Trafficking · correlation 0.95
- Ubiquitin-ERAD Proteostasis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.