CAP1 — Cyclase associated actin cytoskeleton regulatory protein 1

CAP1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CAP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1 +14 more	View in SCUBA
CD4⁺ T cells	Cytoskeleton & metabolism Cytoskeletal	ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, LCK, MYL6, NEDD8, PPP1R18 +11 more	View in SCUBA
CD8⁺ T cells	Actin Cytoskeleton Dynamics Cytoskeletal	ACTG1, ACTR3, ANXA11, ARPC2, CDK2AP2, RAC2, RNF181	View in SCUBA
Endothelial	Actin Cytoskeletal Remodeling Cytoskeletal	ACTR2, ANKRD11, ARPC4, EIF4G1, FYTTD1, G3BP1, GSPT1, IPO7 +8 more	View in SCUBA
Fibroblasts	Actin-Integrin Adhesion Migration & adhesion	ACTR2, ACTR3, C5orf24, CD151, DEGS1, FERMT2, GNB1, ITGB1 +5 more	View in SCUBA
Gamma-delta T cells	Actin Remodeling Cytoskeletal	AP1M1, APOBEC3C, ATP5PB, CAPN1, CAPZB, DBNL, LSP1, PIH1D1 +10 more
Glial cells	Oxidative Stress Response Stress	CD59, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NDUFA11, NFE2L2 +3 more	View in SCUBA
Goblet cells	Actin Cytoskeletal Remodeling Cytoskeletal	ACTN4, ACTR3, BHLHE40, FHL2, KCNK1, LRP10, SDCBP, SLC7A11 +3 more	View in SCUBA
Innate lymphoid cells	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP5F1D, MRPL51, NDUFB11, NOP10, PARK7, POLR2F, PSMB3, VDAC1	View in SCUBA
Lymphatic endothelial	Glycolytic Housekeeping Housekeeping	CALCOCO2, CANX, DPYSL2, DYNC1I2, EIF2S2, ENO1, GIMAP8, PGAM1 +1 more	View in SCUBA
Macrophages	Autophagy Vesicular Trafficking Vesicular traficking	ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAPRIN1, COLGALT1, CPSF2 +32 more	View in SCUBA
Mucosal-associated invariant T cell	Actin Cytoskeletal Remodeling Cytoskeletal	ANXA6, CASP1, CCT5, CCT6A, DEF6, FGD3, GIMAP6, HNRNPF +7 more
Neutrophils	Pentose Phosphate Pathway Housekeeping	ANXA3, ARPC2, CDA, GYG1, HMGB2, LBR, PGD, SNX3 +1 more
Smooth muscle cells	Membrane Protein Turnover Housekeeping	ATP6AP2, AXL, BSG, CBX6, EI24, MFAP4, SSR2, TCEAL9 +1 more	View in SCUBA

About the gene

Synonyms	CAP
Chromosome	1: 40040233-40072649
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Actin-binding

Function

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.