TFAP2A — Transcription factor AP-2 alpha
TFAP2A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFAP2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Peripheral Glial Myelination Myelination | FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, OLFML3 +7 more | View in SCUBA |
About the gene
| Synonyms | AP-2, AP-2alpha, AP2TF, TFAP2 |
|---|---|
| Chromosome | 6: 10393186-10419659 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.