Peripheral Glial Myelination
Gene co-expression module in Glial cells
| Category | Myelination |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
PMP2 (peripheral myelin protein 2) is a lipid-binding protein expressed in Schwann cells and peripheral glia, a hallmark myelination marker. MAF is a transcription factor critical for Schwann cell identity and myelination. ZEB2 is required for peripheral myelination and Schwann cell differentiation. TFAP2A is a neural crest TF active during Schwann cell specification. OLFML3/OLFML2A are BMP/TGF-β pathway modulators expressed in neural crest-derived cells. TIMP3 inhibits MMPs in the glial ECM niche. TAC1 encodes substance P, a neuropeptide co-expressed with enteric glia. FRMD6 participates in Hippo/contact inhibition signaling. Strongly restored in remission, reduced in inflammation — consistent with a peripheral/enteric glial myelination and identity program.
Genes
FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, OLFML3, PMP2, SH3PXD2A, TAC1, TAX1BP3, TFAP2A, TIMP3, TNS3, ZEB2
Most correlated modules
- Enteric Glial Identity · correlation 0.82
- Glial Adhesion Identity · correlation 0.79
- TGF-beta Response · correlation 0.79
- Collagen ECM Deposition · correlation 0.78
- Glial ECM Scaffold · correlation 0.77
- ECM Homeostatic Regulation · correlation 0.73
- Glial Neural Scaffolding · correlation 0.72
- BMP-SMAD Signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.