KDSR — 3-ketodihydrosphingosine reductase
KDSR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDSR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR +10 more | |
| Glial cells | Peripheral Glial Myelination Myelination | FAM210B, FRMD6, GNAS, MAF, MYL9, OLFML2A, OLFML3, PMP2 +7 more | View in SCUBA |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Export & Processing RNA processing & translation | HLTF, KIAA0040, MRPS12, NOSIP, PCED1B, RAD50, SMIM14, STMN3 +6 more |
About the gene
| Synonyms | DHSR, FVT1, SDR35C1 |
|---|---|
| Chromosome | 18: 63327726-63367228 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism, Sphingolipid metabolism |
Function
Catalyzes the reduction of 3'-oxosphinganine (3- ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.