OLFML3 — Olfactomedin like 3
OLFML3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OLFML3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Complement-secreting Fibroblast Immune interaction | ADI1, ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, FTL +9 more | View in SCUBA |
| Glial cells | Peripheral Glial Myelination Myelination | FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, PMP2 +7 more | View in SCUBA |
| Smooth muscle cells | Microfibrillar ECM Program ECM remodeling | ALDH1A1, CDC42EP3, FGL2, FOXP2, MAB21L2, MFAP2, NREP, PNCK +2 more | View in SCUBA |
About the gene
| Synonyms | HNOEL-iso, OLF44 |
|---|---|
| Chromosome | 1: 113979391-114035572 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
Function
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.