TFB1M — Transcription factor B1, mitochondrial
TFB1M belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFB1M's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | mRNA Export & Processing RNA processing & translation | HLTF, KDSR, KIAA0040, MRPS12, NOSIP, PCED1B, RAD50, SMIM14 +6 more |
About the gene
| Synonyms | CGI-75, mtTFB |
|---|---|
| Chromosome | 6: 155256134-155314493 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding, Methyltransferase, RNA-binding, Transferase |
| Biological process | rRNA processing, Transcription, Transcription regulation |
Function
Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.