NOSIP — Nitric oxide synthase interacting protein
NOSIP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOSIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T quiescence T cell development | CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, RASA3 +6 more | View in SCUBA |
| CD8⁺ T cells | Ribosome Biogenesis RNA processing & translation | BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Mucosal-associated invariant T cell | mRNA Export & Processing RNA processing & translation | HLTF, KDSR, KIAA0040, MRPS12, PCED1B, RAD50, SMIM14, STMN3 +6 more |
About the gene
| Synonyms | CGI-25 |
|---|---|
| Chromosome | 19: 49555468-49590262 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Developmental protein, Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.