mRNA Export & Processing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
TFB1M (mitochondrial transcription factor B1, rRNA methylation/mtDNA transcription), MRPS12 (mitoribosomal small subunit), THOC3 (THO complex, mRNA export/splicing), RAD50 (DNA damage repair/MRN complex), HLTF (helicase-like transcription factor, DNA damage tolerance), UFL1 (UFMylation E3 ligase, ER/ribosome stress). The module is a mix of mitochondrial gene expression, RNA processing, and DNA repair. TFB1M and MRPS12 anchor a mitochondrial transcription component, while RAD50 and HLTF suggest DNA repair. TIMP1 and NOSIP are outliers. The strongest coherent sub-theme is mitochondrial transcription and RNA processing.
Genes
HLTF, KDSR, KIAA0040, MRPS12, NOSIP, PCED1B, RAD50, SMIM14, STMN3, TFB1M, THOC3, TIMP1, TMEM204, UFL1, ZNF302
Most correlated modules
- NF-κB Immune Survival · correlation 0.82
- T cell Survival Regulation · correlation 0.81
- Cytotoxic Effector · correlation 0.81
- Mitochondrial Biogenesis · correlation 0.79
- Chemokine Receptor Migration · correlation 0.78
- ER & Mitochondrial Assembly · correlation 0.73
- MAIT Effector Maturation · correlation 0.73
- Chromatin Maintenance State · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.