HLTF — Helicase like transcription factor
HLTF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HLTF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | CENPU, DNAJC9, EIF2AK1, MRPL52, PIP4K2A, POLE2, SLC12A6, TLN1 +2 more | |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Export & Processing RNA processing & translation | KDSR, KIAA0040, MRPS12, NOSIP, PCED1B, RAD50, SMIM14, STMN3 +6 more |
About the gene
| Synonyms | HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3 |
|---|---|
| Chromosome | 3: 149030127-149086554 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase, Multifunctional enzyme, Transferase |
| Biological process | Transcription, Ubl conjugation pathway |
Function
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.