TGFA — Transforming growth factor alpha
TGFA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TGFA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | TLR5 Bacterial Sensing Antibacterial | ACOX1, CCNJL, ENSG00000285708, HYCC2, ITGAL, MGAM2, NSUN7, PPP4R1 +3 more |
About the gene
| Chromosome | 2: 70447284-70554193 |
|---|---|
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Growth factor, Mitogen |
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.