ITGAL — Integrin subunit alpha L

ITGAL belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ITGAL's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Integrin adhesion migration & adhesion	ATP11B, CD84, CEP85L, CYTH1, HTRA1, MYO7A, PCNX2, PDE4DIP +4 more	View in SCUBA
Gamma-delta T cells	TCR Activation Signaling TCR Signaling	ADCY7, ATP2B4, CYFIP2, DIAPH1, GK5, GLG1, NBEAL2, NFATC3 +4 more
Hematopoietic progenitor cells	Naive B Cell Lymphcyte development	CCR7, CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM +4 more
Macrophages	Myeloid Immune Checkpoint Innate immunity	CD276, CLEC12A, LIMK1, SELENON, SLC27A3, SORT1, SPINT1	View in SCUBA
Monocytes	Non-classical Monocyte Migration Migration & adhesion	ADGRE1, CX3CR1, ITGA4, LILRA1, LTB, SCLT1, SH2D3C, UTRN	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation Signaling TCR Signaling	AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, JADE2, NBR1, PLCB2 +6 more
Natural Killer cells	IFN-stimulated NK Inflammation	AKNA, APOL6, ATM, CTSC, MBP, MXD1, PILRB, PTPRC +4 more	View in SCUBA
Neutrophils	TLR5 Bacterial Sensing Antibacterial	ACOX1, CCNJL, ENSG00000285708, HYCC2, MGAM2, NSUN7, PPP4R1, SULT1B1 +3 more

About the gene

Synonyms	CD11A, LFA-1, LFA1A
Chromosome	16: 30472658-30523567
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Molecular function	Integrin, Receptor
Biological process	Cell adhesion, Host-virus interaction, Phagocytosis

Function

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.