ACOX1 — Acyl-CoA oxidase 1
ACOX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACOX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte fatty-acid catabolism Lipid metabolism | ACSL5, CYP3A5, GDA, MIA2, MUC3A, OGDH, RIOK3 | View in SCUBA |
| Neutrophils | TLR5 Bacterial Sensing Antibacterial | CCNJL, ENSG00000285708, HYCC2, ITGAL, MGAM2, NSUN7, PPP4R1, SULT1B1 +3 more |
About the gene
| Synonyms | PALMCOX |
|---|---|
| Chromosome | 17: 75941507-75979177 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long- chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl- CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl- CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.