PPP4R1 — Protein phosphatase 4 regulatory subunit 1
PPP4R1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP4R1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1 +27 more | View in SCUBA |
| Neutrophils | TLR5 Bacterial Sensing Antibacterial | ACOX1, CCNJL, ENSG00000285708, HYCC2, ITGAL, MGAM2, NSUN7, SULT1B1 +3 more |
About the gene
| Synonyms | PP4R1 |
|---|---|
| Chromosome | 18: 9546791-9615240 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF- kappa-B activation by regulating the dephosphorylation of TRAF2. (Microbial infection) Participates in merkel polyomavirus- mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.