TLR5 Bacterial Sensing
Gene co-expression module in Neutrophils
| Category | Antibacterial |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
This module has lower expression and pct positive (~26%), suggesting a rarer neutrophil state or lowly expressed regulatory program. TLR5 is the flagellin pattern recognition receptor, placing this in bacterial sensing. ITGAL (CD11a/LFA-1 alpha) mediates neutrophil adhesion and is upregulated during activation. ACOX1 is the rate-limiting enzyme of peroxisomal fatty acid beta-oxidation, linking to lipid metabolism during activation. TGFA signals through EGFR and is produced by activated myeloid cells. SULT1B1 sulfates bioactive compounds. CCNJL is a cyclin-like gene. The module is heterogeneous but TLR5, ITGAL, and ACOX1 suggest a bacterial-sensing activated neutrophil substate with metabolic adaptation.
Genes
ACOX1, CCNJL, ENSG00000285708, HYCC2, ITGAL, MGAM2, NSUN7, PPP4R1, SULT1B1, TGFA, TLR5, ZNF586
Most correlated modules
- PI3K Migration Signaling · correlation 0.95
- ER Stress Response · correlation 0.94
- Mature Neutrophil Identity · correlation 0.94
- Granulopoiesis Transcriptional · correlation 0.94
- Endosomal Vesicle Trafficking · correlation 0.94
- Stress Kinase Signaling · correlation 0.93
- Signal Attenuation · correlation 0.92
- Ubiquitin-Proteasome Turnover · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.