TIMP4 — TIMP metallopeptidase inhibitor 4
TIMP4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIMP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Tissue-Resident Macrophage Lysosomal & pahgocytosis | AP2A2, BLVRB, CD163, FAH, FCGRT, HTRA1, MKKS, MYO7A +6 more | View in SCUBA |
About the gene
| Chromosome | 3: 12153068-12158912 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor |
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.