BLVRB — Biliverdin reductase B
BLVRB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BLVRB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | DAAM1, HMGN3, LARP6, PCBP2, POLE4, PRKAG2, PRPSAP1, PRR5 +2 more | View in SCUBA |
| Enterocytes | Metallothionein metal response Stress | MT1E, MT1F, MT1G, MT1H, MT1M, MT1X, MT2A, TMEM176A +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | HBQ1, HES6, MPC2, MPST, REXO2, SMIM10, TMEM14B, TMEM14C +2 more | |
| Monocytes | Tissue-Resident Macrophage Lysosomal & pahgocytosis | AP2A2, CD163, FAH, FCGRT, HTRA1, MKKS, MYO7A, RNASE1 +6 more | View in SCUBA |
About the gene
| Synonyms | FLR, SDR43U1 |
|---|---|
| Chromosome | 19: 40447765-40465764 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase, Transferase |
Function
Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase. Promotes fetal heme degradation during development. Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling. Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver. Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult. Does not reduce bilirubin IXalpha. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1. S- nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S- nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S- nitroso-BLVRB to the protein substrate. Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.