Tissue-Resident Macrophage
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes CD163 (hemoglobin-haptoglobin scavenger receptor, the most specific M2/anti-inflammatory macrophage marker), STAB1 (stabilin-1, M2 macrophage scavenger receptor for modified LDL and other ligands), VSIG4 (V-set immunoglobulin domain containing 4, complement receptor expressed on tissue-resident macrophages), FCGRT (neonatal Fc receptor for IgG recycling), RNASE1, BLVRB (biliverdin reductase B, heme catabolism linked to CD163 function), and TFPI (anticoagulant) define a tissue-resident, homeostatic/M2 macrophage scavenging program. This module is closely related to M25 (M2 polarization) but emphasizes scavenger receptor-mediated clearance functions. CD163 and STAB1 co-expression is a hallmark of tissue-resident anti-inflammatory macrophages.
Genes
AP2A2, BLVRB, CD163, FAH, FCGRT, HTRA1, MKKS, MYO7A, RNASE1, STAB1, TBC1D16, TFPI, TIMP4, TMIGD3, VSIG4
Most correlated modules
- M2 Macrophage Polarization · correlation 0.82
- Stress-Adapted Macrophage · correlation 0.74
- IL-18 Inflammasome Response · correlation 0.70
- Efferocytosis Tissue Macrophage · correlation 0.68
- Monocyte Identity · correlation 0.66
- Inflammatory Monocyte Activation · correlation 0.57
- M2 Macrophage Polarization · correlation 0.54
- Glucocorticoid Response · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.