TLE3 — TLE family member 3, transcriptional corepressor
TLE3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TLE3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, AGFG1, CCND3, CD164, CHMP2B, DBF4, GHITM, HNRNPL +9 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Monocytes | AMPK-FOXO Stress Response Stress | AHCTF1, C15orf39, FOXO3, FURIN, IRF2BP2, JARID2, MIDN, PRKAG2 | View in SCUBA |
| Neutrophils | Myeloid Inflammatory Activation Inflammatory | AQP9, CPD, FPR1, ITGAX, LITAF, MXD1, NABP1, NAMPT +5 more |
About the gene
| Synonyms | ESG, ESG3, GRG3, HsT18976, KIAA1547 |
|---|---|
| Chromosome | 15: 70047790-70098176 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.