DKK3 — Dickkopf WNT signaling pathway inhibitor 3
DKK3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DKK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Homeostatic Fibroblast Identity ECM production | ADGRL2, C1S, DCN, DPYSL2, IL34, IL6ST, LUM, PARM1 +6 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, GGA2, GSTM3 +15 more | |
| Glial cells | Enteric Glial Identity Development | COL8A1, DPYSL2, NLGN4X, SCD, SOX10, TENM3, WLS | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DSE, EPAS1, FKBP5, FYN, GLIPR1, H1-10 +16 more | |
| Pericytes | Basement Membrane Remodeling ECM remodeling | ADA, C4orf48, CYBA, EFEMP2, G0S2, ISG20, LAMB3, RCN3 +2 more | View in SCUBA |
| Smooth muscle cells | BMP-ID3 Matricellular Development | ANXA1, HAPLN3, ID3, SH3BGRL3, SMOC2, STOM, TAGLN2 | View in SCUBA |
About the gene
| Synonyms | CRRL, REIC, RIG |
|---|---|
| Chromosome | 11: 11956207-12009769 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Wnt signaling pathway |
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.