AKIRIN2 — Akirin 2
AKIRIN2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKIRIN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th1 IL12 response Immune regulation | ADCY3, CTNNA1, ETV7, HIVEP3, IL12RB2, JAKMIP1, PTPN1, RFTN1 +2 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2, GSTM3 +15 more | |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3, ELOVL5 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT3 Cytokine Signaling Inflammation | AKAP13, AKNA, ARGLU1, BDP1, GOLGB1, H1-2, LCP1, PPP4R3B +4 more | |
| Natural Killer cells | Inflammatory Stress Response Stress | CCNH, CEBPD, CLASP1, FKBP5, H3C1, P2RX5, PARP8, PIK3IP1 +2 more | View in SCUBA |
About the gene
| Synonyms | C6orf166, dJ486L4.2, FLJ10342 |
|---|---|
| Chromosome | 6: 87674860-87702233 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Repressor |
| Biological process | Adaptive immunity, Immunity, Innate immunity, Protein transport, Transcription, Transcription regulation, Transport |
Function
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore. Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.